a Record control number WOS:000303110300016

a ISSN 0890-5096

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WG100

b Item number .A87 2012

a Personal name Bayrak, Serdar.

h Medium Electronic Document

a Title Assessment of Protective Effects of Methylprednisolone and Pheniramine Maleate on Reperfusion Injury in Kidney After Distant Organ Ischemia: A Rat Model

c Statement of responsibility, etc Serdar Bayrak, Ismail Yurekli, Orhan Gokalp, Muge Kiray, Mehmet Senel Bademci, Barcin Ozcem, Yuksel Besir, Levent Yilik, Mert Kestelli, Ali Gurbuz.

a Place of publication, distribution, etc Elsevier science inc,

c Date of publication, distribution, etc 2012.

a Summary, etc Background: Ischemia/reperfusion (I/R) injury of tissues is a common problem that cardiovascular surgeons are faced with. Suppression of inflammation, which plays an important role in the pathogenesis of I/R injury, may reduce this damage. The aim of this study is to investigate the protective effects of methylprednisolone (MP)-a potent anti-inflammatory agent-and pheniramine maleate (FM)-an antihistamine that also has some anti-inflammatory effects-on reperfusion injury of kidneys developing after ischemia of the left lower extremity of rats.Methods: Twenty-eight randomly selected male Sprague-Dawley rats weighing 320 to 370 g were divided into four groups, each consisting of seven rats. Group 1 was the control group. Group 2 was the sham group. Rats in group 3 were subjected to I/R and given FM, and rats in group 4 were subjected to I/R and given MP. A tourniquet was applied at the level of the left groin to subjects in group 2 after induction of anesthesia. One hour of ischemia was performed, and no drug was administered. In group 3, half of a total dose of 10 mg/kg FM was administered before ischemia, and the remaining half was given intraperitoneally before reperfusion. In group 4, subjects received a single dose of 50 mg/kg MP intraperitoneally in the 30th minute of ischemia. Kidneys of all subjects were removed after 24 hours. Extracted tissues were investigated regarding histological and biochemical parametersResults: Malondialdehyde -the end product of lipid peroxidation as an important indicator of I/R injury-levels were significantly lower in group 3 than in group 2 (P < 0.05). Malondialdehyde levels were also lower in group 4 than in group 2, but this difference was insignificant (P > 0.05). Superoxide dismutase and glutathione peroxidase enzyme activities were found to be significantly higher in group 3 than in group 2 (P < 0.05). However, there was no difference between group 4 and group 2 in terms of these activities. Histological examination demonstrated that both MP and FM had protective effects against I/R injury, but this effect was more potent for FM than for MP.Conclusions: FM has a protective effect against reperfusion injury in rat kidney after distant organ ischemia.

a Topical term or geographic name as entry element Cardiovascular system

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Main entry heading Annals of vascular surgery

g Relationship information MAY 2012, Vol 26 Issue 4, p559-565

x International Standard Serial Number 0890-5096

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1016/j.avsg.2012.01.006